Author + information
- Received February 16, 2016
- Accepted February 16, 2016
- Published online June 29, 2016.
- Ronan Abgral, MD, PhDa,b,
- Marc R. Dweck, MD, PhDa,c,∗ (, )
- Maria Giovanna Trivieri, MD, PhDa,
- Philip M. Robson, PhDa,
- Nicolas Karakatsanis, PhDa,
- Venkatesh Mani, PhDa,
- Maria Padilla, MDd,
- Marc Miller, MDe,
- Anuradha Lala, MDe,
- Javier Sanz, MDe,
- Jagat Narula, MD, PhDe,
- Valentin Fuster, MD, PhDe,
- Johanna Contreras, MDe,
- Jason C. Kovacic, MD, PhDe and
- Zahi A. Fayad, PhDa
- aTranslational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York
- bDepartment of Nuclear Medicine, European University of Brittany, EA3878 GETBO, CHRU Brest, Brest, France
- cBritish Heart Foundation/University Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom
- dDivision of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York
- eCardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York
- ↵∗Reprint requests and correspondence:
Dr. Marc R. Dweck, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P.O. Box 1234, New York, New York 10029-6574.
The assessment of both the pattern and activity of myocardial injury has important implications for the clinical management of patients with cardiovascular disease. Comprehensive evaluation of these has previously been challenging using a single imaging modality.
Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) has become well established for differentiating the patterns of injury observed in a range of conditions. 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) is widely used to measure inflammation activity in the vasculature and myocardium.
The advent of simultaneous PET/MR imaging now allows combination of these 2 techniques alongside cardiac function with major advantages in terms of image coregistration, interpretation, and radiation exposure. In this report, we present 3 clinical cases (Figures 1 to 3⇓⇓, Online Videos 1, 2, 3, and 4) where the initial etiology and activity of the disease process was unclear but resolved after addition of FDG PET/MR (Biograph mMR, Siemens, Healthineers, Erlangen, Germany) to the clinical context. A fourth case (Figure 4, Online Videos 5 and 6) highlights the potential for false positive FDG signal in the myocardium (1).
Hybrid FDG-PET/MR offers complementary information with the ability to image myocardial function, the pattern of injury, and disease activity in a single scan.
For supplementary videos, please see the online version of this article.
This work was supported by a National Institutes of Health/National Heart, Lung, and Blood Institute grant R01HL071021 (to Z.A.F.). Dr. Dweck is supported by the British Heart Foundation (FS/14/78/31020). Dr. Narula has received institutional equipment grants from Philips and GE Healthcare; and speaking honoraria from GE Healthcare. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Abgral and Dweck contributed equally to this work. Ami Iskandrian, MD, served as Guest Editor for this paper.
- Received February 16, 2016.
- Accepted February 16, 2016.
- American College of Cardiology Foundation